The primary objective is to measure the burden of AS in the population in primary and secondary care and to identify early predictors of a poor outcome.
The secondary objective is to collect biological samples (serum and DNA) from participants to participate in international studies examining the genetic influence on disease aetiology and to examine within SIRAS whether genetic and serological factors predict poor outcome.
A similiar Database has already been established in Scotland and Northern Ireland under the supervision of Prof G McFarlane (University of Dundee). It is the intention to commence a similar database here in the Republic of Ireland. The ASRI database will therefore document all AS patients attending Rheumatology clinics in Ireland. It will be used to study outcome measures as well as responses to therapy. The identification of factors that might predict a poor prognosis will be a major area research focus.
This database will record patient demographics, treatment including biologic therapy and outcomes. The primary objective is to measure the burden of AS in the population, primary and secondary care. We would then establish an inception cohort in order to identify early predictors of a poor outcome.